P. Cheung

Dr Po-Yin Cheung

(Adjunct Professor)


Office: 9-50 Medical Sciences Bldg.  (☎) 780.716.2818
Lab: 9-50 Medical Sciences Bldg.  (☎) 780.492.3159

MBBS, University of Hong Kong, 1985
PhD (Pharmacology), University of Alberta, 1998
FRCP, Canada & Edinburgh, 2001 & 2002

Teaching: PMCOL425, PMCOL515, PMCOL525


Novel interventions to improve the recovery from neonatal asphyxia

Research Interests / Laboratory Techniques

Cardiovascular Physiology and Pharmacology During Hypoxia and Reoxygenation in Newborns. My research consists of both clinical as well as basic science studies in the neonate. I investigate the effects of novel interventions in critically ill neonates and the long-term outcome in early childhood. Newborn piglet is the animal model used in the laboratory for basic science studies. The current focus of the Neonatal Sciences Laboratory is on the effects of hypoxia-reoxygenation injury and the actions of inotrope and other cardiovascular supportive drugs in systemic and regional circulations and platelet functions.

Selected Recent Publications

Vento M, Schmölzer G, Cheung PY, Finer N, Solevåg AL, Oei JL and Saugstad OD. (2016) What initial oxygen is best for preterm infants in the delivery room?-A response to the 2015 neonatal resuscitation guidelines. Resuscitation [Epub ahead of print]. PMID: 26827713.

Li ES, Cheung PY, O'Reilly M, LaBossiere J, Lee TF, Cowan S, Bigam DL and Schmölzer GM. (2016) Exhaled CO2 Parameters as a Tool to Assess Ventilation-Perfusion Mismatching during Neonatal Resuscitation in a Swine Model of Neonatal Asphyxia. PLoS One 11(1):e0146524. PMID: 26766424.

van Os S, Cheung PY, Kushniruk K, O'Reilly M, Aziz K and Schmölzer GM. (2016) Assessment of endotracheal tube placement in newborn infants: a randomized controlled trial. J Perinatol [Epub ahead of print]. PMID: 26765556.

Pichler G, Urlesberger B, Baik N, Schwaberger B, Binder-Heschl C, Avian A, Pansy J, Cheung PY and Schmölzer GM. (2016) Cerebral Oxygen Saturation to Guide Oxygen Delivery in Preterm Neonates for the Immediate Transition after Birth: A 2-Center Randomized Controlled Pilot Feasibility Trial. J Pediatr 170:73-78. PMID: 26743498.

Fortin-Pellerin E, Khoo NS, Mills L, Coe JY, Serrano-Lomelin J, Cheung PY and Hornberger LK. (2016) Postnatal neonatal myocardial adaptation is associated with loss of tolerance to tachycardia: a simultaneous invasive and noninvasive assessment. Am J Physiol Heart Circ Physiol310(5):H598-607. PMID: 26718970.

Solevåg AL, Cheung PY, O'Reilly M and Schmölzer GM. (2016) A review of approaches to optimise chest compressions in the resuscitation of asphyxiated newborns. Arch Dis Child Fetal Neonatal Ed [Epub ahead of print]. PMID: 26627554.

Yoshida S, Martines J, Lawn JE, Wall S, Souza JP, Rudan I, Cousens S; neonatal health research priority setting group, Aaby 8, Adam I, Adhikari RK, Ambalavanan N, Arifeen SE, Aryal DR, Asiruddin S, Baqui A, Barros AJ, Benn CS, Bhandari V, Bhatnagar S, Bhattacharya S, Bhutta ZA, Black RE, Blencowe H, Bose C, Brown J, Bührer C, Carlo W, Cecatti JG, Cheung PY, Clark R, Colbourn T, Conde-Agudelo A, Corbett E, Czeizel AE, Das A, Day LT, Deal C, Deorari A, Dilmen U, English M, Engmann C, Esamai F, Fall C, Ferriero DM, Gisore P, Hazir T, Higgins RD, Homer CS, Hoque DE, Irgens L, Islam MT, de Graft-Johnson J, Joshua MA, Keenan W, Khatoon S, Kieler H, Kramer MS, Lackritz EM, Lavender T, Lawintono L, Luhanga R, Marsh D, McMillan D, McNamara PJ, Mol BW, Molyneux E, Mukasa GK, Mutabazi M, Nacul LC, Nakakeeto M, Narayanan I, Olusanya B, Osrin D, Paul V, Poets C, Reddy UM, Santosham M, Sayed R, Schlabritz-Loutsevitch NE, Singhal N, Smith MA, Smith PG, Soofi S, Spong CY, Sultana S, Tshefu A, van Bel F, Gray LV, Waiswa P, Wang W, Williams SL, Wright L, Zaidi A, Zhang Y, Zhong N, Zuniga I and Bahl R. (2016) Setting research priorities to improve global newborn health and prevent stillbirths by 2025. J Glob Health 6(1):010508. PMID: 26401272.

Solevag AL, Cheung PY, Lie H, O'Reilly M, Aziz K, Nakstad B and Schmolzer GM. (2015) Chest compressions in newborn animal models: A review. Resuscitation 96:151-155. PMID: 26296586.

Nicoll J, Cheung PY, Aziz K, Rajani V, O'Reilly M, Pichler G and Schmolzer GM. (2015) Exhaled Carbon Dioxide and Neonatal Breathing Patterns in Preterm Infants after Birth. J Pediatr 167(4):829-833 PMID: 26227435.

Li ES, Cheung PY, O'Reilly M and Schmolzer GM. (2015) Change in tidal volume during cardiopulmonary resuscitation in newborn piglets. Arch Dis Child Fetal Neonatal Ed 100(6):F530-3. PMID: 26139543.

Pichler G, Baik N, Urlesberger B, Cheung PY, Aziz K, Avian A and Schmolzer GM. (2016) Cord clamping time in spontaneously breathing preterm neonates in the first minutes after birth: impact on cerebral oxygenation - a prospective observational study. J Matern Fetal Neonatal Med 29(10):1570-2. PMID: 26103783.

Mian Q, Cheung PY, O'Reilly M, Pichler G, van Os S, Kushniruk K, Aziz K and Schmolzer GM. (2015) Spontaneously Breathing Preterm Infants Change in Tidal Volume to Improve Lung Aeration Immediately after Birth. J Pediatr 167(2):274-278. PMID: 25998060.

Bianchi MO, Cheung PY, Phillipos E, Aranha-Netto A and Joynt C. (2015) The Effect of Milrinone on Splanchnic and Cerebral Perfusion in Infants With Congenital Heart Disease Prior to Surgery: An Observational Study. Shock 44(2):115-20. PMID: 25895150.

Follett G, Cheung PY, Pichler G, Aziz K and Schmolzer GM. (2015) Time needed to achieve changes in oxygen concentration at the T-Piece resuscitator during respiratory support in preterm infants in the delivery room. Paediatr Child Health 20(2):e10-2. PMID: 25838786.

Morton JS, Andersson IJ, Cheung PY, Baker P and Davidge ST. (2015) The vascular effects of sodium tanshinone IIA sulphonate in rodent and human pregnancy. PLoS One 10(3):e0121897. PMID: 25811628.

Cheung D, Mian Q, Cheung PY, O'Reilly M, Aziz K, van Os S, Pichler G and Schmolzer GM. (2015) Mask ventilation with two different face masks in the delivery room for preterm infants: a randomized controlled trial. J Perinatol 35(7):464-8. PMID: 25719544.

Pichler G, Cheung PY, Tze-Fun L, Li ES and Schmolzer GM. (2014) Is renal tissue oxygen desaturation during severe hypoxia underestimated? An observational study in term newborn piglets. Nephrology (Carlton) 20(2):107-9. PMID: 25619650.

Schmolzer GM, Kumar M, Aziz K, Pichler G, O'Reilly M, Lista G and Cheung PY. (2014) Sustained inflation versus positive pressure ventilation at birth: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 100(4):F361-8. PMID: 25550472.

Pichler G, Cheung PY, Binder C, O'Reilly M, Schwaberger B, Aziz K, Urlesberger B and Schmolzer GM. (2014) Time course study of blood pressure in term and preterm infants immediately after birth. PLoS One 9(12):e114504. PMID: 25514747.

Morton JS, Quon A, Cheung PY, Sawamura T and Davidge ST. (2015) Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia. Am J Physiol Regul Integr Comp Physiol 308(3):R163-72. PMID: 25477421.

Li ES, Cheung PY, O'Reilly M, Aziz K, and Schmolzer GM. (2014) Rescuer fatigue during simulated neonatal cardiopulmonary resuscitation. J Perinatol 35(2):142-5. PMID: 25211285.

Labossiere JR, Pelletier JS, Thiesen A, Schulz R, Bigam DL and Cheung PY. (2015) Doxycycline attenuates renal injury in a swine model of neonatal hypoxia-reoxygenation. Shock 43(1):99-105. PMID: 25105465.

Mian QN, Pichler G, Binder C, O'Reilly M, Aziz K, Urlesberger B, Cheung PY and Schmolzer GM. (2014) Tidal Volumes in Spontaneously Breathing Preterm Infants Supported with Continuous Positive Airway Pressure. J Pediatr 165(4):702-6. PMID: 25070013.

Kang LJ, Cheung PY, Pichler G, O'Reilly M, Aziz K and Schmolzer GM. (2014) Monitoring lung aeration during respiratory support in preterm infants at birth. PLoS One 9(7):e102729. PMID: 25029553.

van Os S, Cheung PY, Pichler G, Aziz K, O'Reilly M, and Schmolzer GM. (2014) Exhaled carbon dioxide can be used to guide respiratory support in the delivery room. Acta Paediatr 103(8):796-806. PMID: 24698203.

Janvier A, Barrington KJ, Aziz K, Bancalari E, Batton D, Bellieni C, Bensouda B, Blanco C, Cheung PY, Cohn F,Daboval T, Davis P, Dempsey E, Dupont-Thibodeau A, Ferretti E, Farlow B, Fontana M, Fortin-Pellerin E, Goldberg A, Hansen TW, Haward M, Kovacs L, Lapointe A, Lantos J, Morley C, Moussa A, Musante G, Nadeau S, O'Donnell CP, Orfali K, Payot A, Ryan CA, Sant'anna G, Saugstad OD, Sayeed S, Stokes TA, Verhagen E. (2014) CPS position statement for prenatal counselling before a premature birth: Simple rules for complicated decisions. Paediatr Child Health 19 (1):22-24. PMID: 24627651.

Pelletier JS, Dicken B, Bigam D, Cheung PY. (2014) Cardiac Effects of Vasopressin. J Cardiovasc Pharmacol 64(1):100-7. PMID: 24621650.