P. Light

Dr Peter Light

(Professor)

Contact:

Office: 1-005 Li Ka Shing Centre  (☎) 780.492.0638
Lab: 6-040 Li Ka Shing Centre  (☎) 780.492.6150
peter.light@ualberta.ca

Education:
1986/09-1990/06 PhD (Biological Sciences / Cell Physiology), University of Birmingham, United Kingdom
1983/09-1986/06 BSc – Honours (Biological Sciences / Cell Physiology), University of Birmingham, United Kingdom

Teaching: PHARM367, PMCOL343, PMCOL371, PMCOL514*, DMED514

Research: The Light lab aims to discover new therapies for heart disease and diabetes


Research Interests / Laboratory Techniques

Dr Light is an international leader in the field of cellular electrical activity. His research is focused on three primary areas:

1) Islet signaling and diabetes;

2) Islet engineering;

3) Cardiac ischemia reperfusion injury;

He is focused on understanding the relationship between dietary fats and insulin secretion in type 2 diabetes and has made important contributions to our current knowledge of how diet and genetic background may be linked to type 2 diabetes susceptibility.


Selected Recent Publications / Recent Funding

Hamza SM, Sung MM, Gao F, Soltys CM, Smith NP, MacDonald PE, Light PE and Dyck JR. (2017) Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats. Biochim Biophys Acta 1861(2):313-322. PMID: 27871838.

Baczko I and Light PE. (2015) Resveratrol and derivatives for the treatment of atrial fibrillation. Ann NY Acad Sci 1348(1):68-74. PMID: 26205342.

Fatehi M, Carter CR, Youssef N, Hunter BE, Holt A and Light PE. (2015) Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity. Biosci Rep 35(4) pii: e00238. PMID: 26181369.

Sung MM, Zordoky BN, Bujak AL, Lally JS, Fung D, Young ME, Horman S, Miller EJ, Light PE, Kemp BE, Steinberg GR and Dyck, JR. (2015) AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism. Cardiovasc Res 107(2):235-45. PMID: 26023060.

Abdelmoneim AS, Eurich DT, Light PE, Senior PA, Seubert JM, Makowsky MJ and Simpson SH. (2015) The Cardiovascular Safety of Sulfonylureas: More than Forty Years of Continuous Controversy without an Answer. Diabetes Obes Metab 17(6):523-32. PMID: 25711240.

Yue JT, Abraham MA, Lapierre MP, Mighiu PI, Light PE, Filippi BM and Lam TK. (2015) A fatty acid-dependent hypothalamic-DVC neurocircuitry that regulates hepatic secretion of triglyceride-rich lipoproteins. Nat Commun 6:5970. PMID: 25580573.

Narang D, Kerr PM, Lunn SE, Beaudry R, Sigurdson J, Lalies MD, Hudson AL, Light PE, Holt A and Plane F. (2014) Modulation of Resistance Artery Tone by the Trace Amine beta-Phenylethylamine: Dual Indirect Sympathomimetic and alpha1-Adrenoceptor Blocking Actions. J Pharmacol Exp Ther 351 (1):164-171. PMID: 25118217.

Ezekowitz JA, Becher H, Belenkie I, Clark AM, Duff HJ, Friedrich MG, Haykowsky MJ, Howlett JG, Kassiri Z, Kaul P, Kim DH, Knudtson ML, Light PE, Lopaschuk GD, McAlister FA, Noga ML, Oudit GY, Paterson DI, Quan H, Schulz R, Thompson RB, Weeks SG, Anderson TJ and Dyck JR. (2014) The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study. BMC Cardiovasc Disord. 14:91. PMID: 25063541.

Yu Y, Carter CR, Youssef N, Dyck JR, Light PE. (2014) Intracellular Long-Chain Acyl CoAs Activate TRPV1 Channels. PLoS One 9(5):e96597. PMID: 24798548.

Abraham MA, Yue JT, Lapierre MP, Rutter GA, Light PE, Filippi BM, Lam TK. (2013) Hypothalamic glucagon signals through the KATP channels to regulate glucose production. Mol Metab 3 (2):202-208, . PMID: 24634823.

Samokhvalov V, Alsaleh N, El-Sikhry HE, Jamieson KL, Chen CB, Lopaschuk DG,Carter C, Light PE, Manne R, Falck JR and Seubert JM (2013) Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response. Cell Death Dis 4:e885. PMID: 24157879.

Baczko I, Liknes D, Yang W, Hamming KC, Searle G, Jaeger K, Husti Z, Juhasz V, Klausz G, Pap R, Saghy L, Varro A, Dolinsky V, Wang S, Rauniyar V, Hall D, Dyck JR, Light PE. (2013) Characterization of a novel multi-functional resveratrol derivative for the treatment of atrial fibrillation. Br J Pharmacol 18:12409. PMID: 24102184.

Soliman D, Wang L, Hamming KS, Yang W, Fatehi M, Carter CC, Clanachan AS, Light PE. (2012) Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange. J Pharmacol Exp Ther 343:325-332. PMID: 22879384.

Batchu SN, Chaudhary KR, El-Sikhry H, Yang W, Light PE, Oudit GY and Seubert JM (2012) Role of PI3Kalpha and sarcolemmal ATP-sensitive potassium channels in epoxyeicosatrienoic acid mediated cardioprotection. J Mol Cell Cardiol 53:43-52. PMID: 22561102.

Lang VY, Fatehi M, Light PE. (2012) Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A. Pharmacogenetics and Genomics 22:206-214. PMID: 22209866.